FLUKA and micro-PET ?

From: Rollet Sofia (Sofia.Rollet@arcs.ac.at)
Date: Mon Aug 20 2007 - 12:15:31 CEST

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    Dear FLUKA Team and users,

    Is there any possibility/interest to use FLUKA to simulate the
    distribution of a positron-emitting radioisotope, such as 18F, in small
    leaving animals and comparing it with a micro-PET scan?

    =20

    I saw the interesting work done by Parodi, Ferrari, Sommerer and
    Paganetti to calculate the dose and positron emitter distributions in
    proton therapy, mainly with 11C and 15O but I couldn't find anything
    else with radionuclide tracers. From this work, I saw that it is
    possible the compute the positron emitter distribution using the
    RESNUCLEi or combining the proton fluence with the cross-sections. I
    suppose it is impossible to use FLUKA to simulate the bio-kinetics but
    it should be possible calculated the electron-positron distribution
    assuming the radionuclide concentration in a certain region, but I
    wonder if this can be of any interest. =20

    =20

    As some of you know, I am using FLUKA since many, many years for a
    variety of application but I never worked with PET. Since here in
    Seibersdorf another group is producing radiopharmaceuticals and using
    them to study bio-kinetics
    (http://www.healthphysics.at/getbinobj.asp?id=3D1314) I have been asked =
    to
    investigate the possibility to compare their measurements with
    simulation. I wonder if some of you already did a similar work and can
    give me some references and/or there is any interest in such a
    comparison or collaboration.=20

    =20

    Thank you in advance for any reply and suggestion.

    Best regards,

    Sofia Rollet=20

    =20

    ________________________________

    =20

    Sofia Rollet

    =20

    Radiation Safety and Applications

    Risk and Safety

    Austrian Research Centers GmbH -ARC

    A-2444 Seibersdorf, Austria

    =20

    Phone: +43 (0)50550 - 2482

    Fax: +43 (0)50550 - 2502=20

    E-mail: sofia.rollet@arcs.ac.at <mailto:sofia.rollet@arcs.ac.at>=20

    Web: http://www.healthphysics.at <http://www.healthphysics.at/>=20

    =20

    ________________________________

    =20

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    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>Dear FLUKA Team and =
    users,<o:p></o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>Is there any possibility/interest to use FLUKA =
    to
    simulate the distribution of a positron-emitting radioisotope, such as =
    18F, in small
    leaving animals and comparing it with a micro-PET =
    scan?<o:p></o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'><o:p>&nbsp;</o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>I saw the interesting work done by Parodi, =
    Ferrari,
    Sommerer and Paganetti to calculate the dose and positron emitter =
    distributions
    in proton therapy, mainly with 11C and 15O but I couldn&#8217;t find =
    anything else
    with radionuclide tracers. From this work, I saw that it is possible the
    compute the positron emitter distribution using the RESNUCLEi or =
    combining the
    proton fluence with the cross-sections. I suppose it is impossible to =
    use FLUKA
    to simulate the bio-kinetics but it should be possible calculated the =
    electron-positron
    distribution assuming the radionuclide concentration in a certain =
    region, but I
    wonder if this can be of any interest. =
    &nbsp;<o:p></o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'><o:p>&nbsp;</o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>As some of you know, I am using FLUKA since =
    many,
    many years for a variety of application but I never worked with PET. =
    Since here
    in Seibersdorf another group is producing radiopharmaceuticals and using =
    them to
    study bio-kinetics (<a =
    href=3D"http://www.healthphysics.at/getbinobj.asp?id=3D1314">http://www.h=
    ealthphysics.at/getbinobj.asp?id=3D1314</a>)
    I have been asked to investigate the possibility to compare their =
    measurements
    with simulation. I wonder if some of you already did a similar work and =
    can give
    me some references and/or there is any interest in such a comparison or
    collaboration. <o:p></o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'><o:p>&nbsp;</o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>Thank you in advance for any reply and =
    suggestion.<o:p></o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>Best regards,<o:p></o:p></span></font></p>

    <p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
    style=3D'font-size:
    10.0pt;font-family:Arial'>Sofia Rollet <o:p></o:p></span></font></p>

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    and
    Applications</span></font><span lang=3DEN-GB><o:p></o:p></span></p>

    <p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
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    GmbH -ARC</span></font><span lang=3DEN-GB><o:p></o:p></span></p>

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