From: Rollet Sofia (Sofia.Rollet@arcs.ac.at)
Date: Mon Aug 20 2007 - 12:15:31 CEST
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Dear FLUKA Team and users,
Is there any possibility/interest to use FLUKA to simulate the
distribution of a positron-emitting radioisotope, such as 18F, in small
leaving animals and comparing it with a micro-PET scan?
=20
I saw the interesting work done by Parodi, Ferrari, Sommerer and
Paganetti to calculate the dose and positron emitter distributions in
proton therapy, mainly with 11C and 15O but I couldn't find anything
else with radionuclide tracers. From this work, I saw that it is
possible the compute the positron emitter distribution using the
RESNUCLEi or combining the proton fluence with the cross-sections. I
suppose it is impossible to use FLUKA to simulate the bio-kinetics but
it should be possible calculated the electron-positron distribution
assuming the radionuclide concentration in a certain region, but I
wonder if this can be of any interest. =20
=20
As some of you know, I am using FLUKA since many, many years for a
variety of application but I never worked with PET. Since here in
Seibersdorf another group is producing radiopharmaceuticals and using
them to study bio-kinetics
(http://www.healthphysics.at/getbinobj.asp?id=3D1314) I have been asked =
to
investigate the possibility to compare their measurements with
simulation. I wonder if some of you already did a similar work and can
give me some references and/or there is any interest in such a
comparison or collaboration.=20
=20
Thank you in advance for any reply and suggestion.
Best regards,
Sofia Rollet=20
=20
________________________________
=20
Sofia Rollet
=20
Radiation Safety and Applications
Risk and Safety
Austrian Research Centers GmbH -ARC
A-2444 Seibersdorf, Austria
=20
Phone: +43 (0)50550 - 2482
Fax: +43 (0)50550 - 2502=20
E-mail: sofia.rollet@arcs.ac.at <mailto:sofia.rollet@arcs.ac.at>=20
Web: http://www.healthphysics.at <http://www.healthphysics.at/>=20
=20
________________________________
=20
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<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>Dear FLUKA Team and =
users,<o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>Is there any possibility/interest to use FLUKA =
to
simulate the distribution of a positron-emitting radioisotope, such as =
18F, in small
leaving animals and comparing it with a micro-PET =
scan?<o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>I saw the interesting work done by Parodi, =
Ferrari,
Sommerer and Paganetti to calculate the dose and positron emitter =
distributions
in proton therapy, mainly with 11C and 15O but I couldn’t find =
anything else
with radionuclide tracers. From this work, I saw that it is possible the
compute the positron emitter distribution using the RESNUCLEi or =
combining the
proton fluence with the cross-sections. I suppose it is impossible to =
use FLUKA
to simulate the bio-kinetics but it should be possible calculated the =
electron-positron
distribution assuming the radionuclide concentration in a certain =
region, but I
wonder if this can be of any interest. =
<o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>As some of you know, I am using FLUKA since =
many,
many years for a variety of application but I never worked with PET. =
Since here
in Seibersdorf another group is producing radiopharmaceuticals and using =
them to
study bio-kinetics (<a =
href=3D"http://www.healthphysics.at/getbinobj.asp?id=3D1314">http://www.h=
ealthphysics.at/getbinobj.asp?id=3D1314</a>)
I have been asked to investigate the possibility to compare their =
measurements
with simulation. I wonder if some of you already did a similar work and =
can give
me some references and/or there is any interest in such a comparison or
collaboration. <o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>Thank you in advance for any reply and =
suggestion.<o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>Best regards,<o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'>Sofia Rollet <o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3DArial><span lang=3DEN-GB =
style=3D'font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
<div>
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style=3D'font-size:12.0pt'>
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</span></font></div>
</div>
<p class=3DMsoNormal><strong><b><font size=3D2 face=3DArial><span =
lang=3DEN-GB
style=3D'font-size:10.0pt;font-family:Arial'><o:p> </o:p></span></fo=
nt></b></strong></p>
<p class=3DMsoNormal><strong><b><font size=3D2 face=3DArial><span =
lang=3DEN-GB
style=3D'font-size:10.0pt;font-family:Arial'>Sofia =
Rollet<o:p></o:p></span></font></b></strong></p>
<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
lang=3DEN-GB
style=3D'font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
lang=3DEN-GB
style=3D'font-size:10.0pt;font-family:Arial;color:gray'>Radiation Safety =
and
Applications</span></font><span lang=3DEN-GB><o:p></o:p></span></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
lang=3DEN-GB
style=3D'font-size:10.0pt;font-family:Arial;color:gray'>Risk and =
Safety</span></font><span
lang=3DEN-GB><o:p></o:p></span></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
lang=3DEN-GB
style=3D'font-size:10.0pt;font-family:Arial;color:gray'>Austrian =
Research Centers
GmbH -ARC</span></font><span lang=3DEN-GB><o:p></o:p></span></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
lang=3DEN-GB
style=3D'font-size:10.0pt;font-family:Arial;color:gray'>A-2444 =
<st1:place w:st=3D"on"><st1:City
w:st=3D"on">Seibersdorf</st1:City></st1:place>, <st1:country-region =
w:st=3D"on">Austria</st1:country-region></span></font><span
lang=3DEN-GB><o:p></o:p></span></p>
<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
lang=3DEN-GB
style=3D'font-size:12.0pt'> <o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
style=3D'font-size:
10.0pt;font-family:Arial;color:gray'>Phone: +43 (0)50550 - =
2482</span></font><o:p></o:p></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
style=3D'font-size:
10.0pt;font-family:Arial;color:gray'>Fax: +43 =
(0)50550
- 2502 </span></font><o:p></o:p></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
style=3D'font-size:
10.0pt;font-family:Arial;color:gray'>E-mail: <u>sofia.ro=
llet</u></span></font><a
href=3D"mailto:sofia.rollet@arcs.ac.at" =
title=3D"mailto:sofia.rollet@arcs.ac.at"><font
color=3Dgray><span style=3D'color:gray'><span =
title=3D"mailto:sofia.rollet@arcs.ac.at">@arcs.ac.at</span></span></font>=
</a><o:p></o:p></p>
<p class=3DMsoNormal><font size=3D2 color=3Dgray face=3DArial><span =
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href=3D"http://www.healthphysics.at/" =
title=3D"http://www.healthphysics.at/"><font
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